Science / Study - 1
menatto® supports healthy bone mineral density in post-menopausal women*


A randomized, double-blind, placebo-controlled study of 244 post-menopausal women found that supplementing with low-dose menatto® vitamin K2 (MK-7) for 3 years helped bind calcium to bones, supporting healthy bone mineral density.*


Previous research has established that vitamin K supports healthy bone metabolism by helping ensure the proper level of carboxylated osteocalcin is present to bind calcium to bone. These studies were conducted with high-dose vitamin K1 (phylloquinone) and K2 (menaquinone-4, MK-4). Because menatto® (menaquinone-7, MK-7) has a longer half-life and greater potency than both K1 and MK-4, researchers tested the efficacy of a lower dose (180 mcg/day).

Study details

Healthy post-menopausal women were randomly assigned to take either menatto® or placebo for 3 years. At baseline and again at 1, 2, and 3 years, researchers measured bone mineral density at several sites in the body, as well as bone strength at the femoral neck. Circulating levels of uncarboxylated osteocalcin (ucOC) and carboxylated osteocalcin (cOC) were also measured. (The ratio of ucOC to cOC is a marker of vitamin K status.)


menatto® significantly improved vitamin K status compared to placebo and helped support bone density and bone strength.*

Knapen MHJ, et al. Osteoporos Int. 2013 Sep;24(9):2499-507.